As the Author of the Locations Extension I haven't tested it explicitly with any Ruleset bar the CoreRPG Ruleset, but as it's all new code (or code that sits on top of the CoreRPG Code) and doesn't touch much if any functionality that would likely to be changed by any Ruleset or Extension based on the CoreRPG, it should work fine.
I'll be releasing version 2.0 in a very small while which adds a whole bunch of new "stuff" (so keep an eye out for it :) ), but even then my above statement should still apply.
Cheers